Ivan Baxter

Dr. Baxter uses high-throughput elemental profiling to measure the elemental composition of plant tissues including soybean seeds and corn kernels. These data are used to perform genetics and modeling to understand how the interactions of elements, genes, and the environment determine the elemental composition of plants and allow plants to adapt to different environments. BA: Chemistry (Goucher College); Ph.D.: Molecular and Cellular Structure and Chemistry (The Scripps Research Institute); Post-doc: Plant Bioinformatics/Ionomics (Purdue University)

RESEARCH | PUBLICATIONS | RESEARCH TEAM | LAB NEWS

Publications

Krishnan, H., Jang, S., Baxter, I., and Weiebold, W. (2012). Growing Location has a Pronounced Effect on the Accumulation of Cancer Chemopreventive Agent Bowman-Birk Inhibitor in Soybean Seeds. Crop Science
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Baxter, I., Hermans, C., Lahner, B., Yakubova, E., Tikhonova, M., Verbruggen, N., Chao, D.Y., and Salt, D.E. (2012). Biodiversity of Mineral Nutrient and Trace Element Accumulation in Arabidopsis thaliana. PLoS One 7, e35121.
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Yu, D., Danku, J., Baxter, I., Kim, S., Vatamaniuk, O.K., Salt, D.E., and Vitek, O. (2011). Noise reduction in genome-wide perturbation screens using linear mixed-effect models. Bioinformatics 27, 2173-2180.
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Chao, D.Y., Gable, K., Chen, M., Baxter, I., Dietrich, C.R., Cahoon, E.B., Guerinot, M.L., Lahner, B., Lu, S., Markham, J.E., Morrissey, J., Han, G., Gupta, S.D., Harmon, J.M., Jaworski, J.G., Dunn, T.M., and Salt, D.E. (2011). Sphingolipids in the Root Play an Important Role in Regulating the Leaf Ionome in Arabidopsis thaliana. Plant Cell 23, 1061-1081.
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Becker, A., Chao, D.Y., Zhang, X., Salt, D.E., and Baxter, I. (2011). Bulk segregant analysis using single nucleotide polymorphism microarrays. PLoS One 6, e15993.
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Tian, H., Baxter, I.R., Lahner, B., Reinders, A., Salt, D.E., and Ward, J.M. (2010). Arabidopsis NPCC6/NaKR1 is a phloem mobile metal binding protein necessary for phloem function and root meristem maintenance. Plant Cell 22, 3963-3979.
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Baxter, I., Brazelton, J.N., Yu, D., Huang, Y.S., Lahner, B., Yakubova, E., Li, Y., Bergelson, J., Borevitz, J.O., Nordborg, M., Vitek, O., and Salt, D.E. (2010). A Coastal Cline in Sodium Accumulation in Arabidopsis thaliana; Is Driven by Natural Variation of the Sodium Transporter AtHKT1;1. PLoS Genet 6, e1001193.
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Atwell, S., Huang, Y.S., Vilhjalmsson, B.J., Willems, G., Horton, M., Li, Y., Meng, D., Platt, A., Tarone, A.M., Hu, T.T., Jiang, R., Muliyati, N.W., Zhang, X., Amer, M.A., Baxter, I., Brachi, B., Chory, J., Dean, C., Debieu, M., de Meaux, J., Ecker, J.R., Faure, N., Kniskern, J.M., Jones, J.D., Michael, T., Nemri, A., Roux, F., Salt, D.E., Tang, C., Todesco, M., Traw, M.B., Weigel, D., Marjoram, P., Borevitz, J.O., Bergelson, J., and Nordborg, M. (2010). Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines. Nature.
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Baxter, I. (2010). Ionomics: The functional genomics of elements. Brief Funct Genomic Proteomic 9, 149-156.
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Buescher, E., Achberger, T., Amusan, I., Giannini, A., Ochsenfeld, C., Rus, A., Lahner, B., Hoekenga, O., Yakubova, E., Harper, J.F., Guerinot, M.L., Zhang, M., Salt, D.E., and Baxter, I.R. (2010). Natural genetic variation in selected populations of Arabidopsis thaliana is associated with ionomic differences. PLoS One 5, e11081.
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(2010). Genome sequencing and analysis of the model grass Brachypodium distachyon. Nature 463, 763-768.
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Morrissey, J., Baxter, I.R., Lee, J., Li, L., Lahner, B., Grotz, N., Kaplan, J., Salt, D.E., and Guerinot, M.L. (2009). The ferroportin metal efflux proteins function in iron and cobalt homeostasis in Arabidopsis. Plant Cell 21, 3326-3338.
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Danku, J., Gumaelius, L., Baxter, I., and Salt, D.E. (2009). A high-throughput method for Saccharomyces cerevisiae (yeast) ionomics. Journal of Analytical Atomic Spectrometry 24, 103-107.
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Baxter, I., Vitek, O., Guerinot, M.L., and Salt, D.E. (2009). Reply to Evens and Niedz: Multivariate ionomics models are robustly validated. Proc Natl Acad Sci U S A 106, E7E7.
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Baxter, I., Hosmani, P.S., Rus, A., Lahner, B., Borevitz, J.O., Muthukumar, B., Mickelbart, M.V., Schreiber, L., Franke, R.B., and Salt, D.E. (2009). Root suberin forms an extracellular barrier that affects water relations and mineral nutrition in Arabidopsis. PLoS Genet 5, e1000492.
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Baxter, I. (2009). Ionomics: studying the social network of mineral nutrients. Curr Opin Plant Biol 12, 381-386.
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Salt, D.E., Baxter, I., and Lahner, B. (2008). Ionomics and the study of the plant ionome. Annu Rev Plant Biol 59, 709-733.
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Eltabakh, M.Y., Ouzzani, M., Aref, W.G., Elmagarmid, A.K., Laura-Silva, Y., Arshad, M.U., Salt, D.E., and Baxter, I. (2008). Managing biological data using bdbms. In IEEE 24th International Conference on Data Engineering (Cancún, México).
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Baxter, I.R., Vitek, O., Lahner, B., Muthukumar, B., Borghi, M., Morrissey, J., Guerinot, M.L., and Salt, D.E. (2008). The leaf ionome as a multivariable system to detect a plant's physiological status. Proc Natl Acad Sci U S A 105, 12081-12086.
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Baxter, I., Muthukumar, B., Park, H.C., Buchner, P., Lahner, B., Danku, J., Zhao, K., Lee, J., Hawkesford, M.J., Guerinot, M.L., and Salt, D.E. (2008). Variation in molybdenum content across broadly distributed populations of Arabidopsis thaliana is controlled by a mitochondrial molybdenum transporter (MOT1). PLoS Genet 4, e1000004.
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Salt, D., Baxter, I., Lahner, B., and Yakubov, L. (2007). Progress in mapping the Arabidopsis ionome. Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology 146, S245-S246.
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Borevitz, J.O., Hazen, S.P., Michael, T.P., Morris, G.P., Baxter, I.R., Hu, T.T., Chen, H., Werner, J.D., Nordborg, M., Salt, D.E., Kay, S.A., Chory, J., Weigel, D., Jones, J.D., and Ecker, J.R. (2007). Genome-wide patterns of single-feature polymorphism in Arabidopsis thaliana. Proc Natl Acad Sci U S A 104, 12057-12062.
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Baxter, I., Ouzzani, M., Orcun, S., Kennedy, B., Jandhyala, S.S., and Salt, D.E. (2007). Purdue ionomics information management system. An integrated functional genomics platform. Plant Physiol 143, 600-611.
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Rus, A., Baxter, I., Muthukumar, B., Gustin, J., Lahner, B., Yakubova, E., and Salt, D.E. (2006). Natural variants of AtHKT1 enhance Na+ accumulation in two wild populations of Arabidopsis. PLoS Genet 2, e210.
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Baxter, I.R., and Borevitz, J.O. (2006). Mapping a plant's chemical vocabulary. Nat Genet 38, 737-738.
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Peer, W., Baxter, I., Richards, E., Freeman, J., and Murphy, A. (2005). Phytoremediation and Hyperacumulator Plants. In Molecular Biology of Metal Homeostasis and Detoxification, M. Tamas and E. Martinoia, eds (Dordrecht, The Netherlands: Springer), pp. 299-340.
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Hazen, S.P., Pathan, M.S., Sanchez, A., Baxter, I., Dunn, M., Estes, B., Chang, H.S., Zhu, T., Kreps, J.A., and Nguyen, H.T. (2005). Expression profiling of rice segregating for drought tolerance QTLs using a rice genome array. Funct Integr Genomics 5, 104-116.
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Baxter, I.R., Young, J.C., Armstrong, G., Foster, N., Bogenschutz, N., Cordova, T., Peer, W.A., Hazen, S.P., Murphy, A.S., and Harper, J.F. (2005). A plasma membrane H+-ATPase is required for the formation of proanthocyanidins in the seed coat endothelium of Arabidopsis thaliana. Proc Natl Acad Sci U S A 102, 2649-2654.
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Baxter, I., Tchieu, J., Sussman, M.R., Boutry, M., Palmgren, M.G., Gribskov, M., Harper, J.F., and Axelsen, K.B. (2003). Genomic comparison of P-type ATPase ion pumps in Arabidopsis and rice. Plant Physiol 132, 618-628.
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Vitart, V., Baxter, I., Doerner, P., and Harper, J.F. (2001). Evidence for a role in growth and salt resistance of a plasma membrane H⁺-ATPase in the root endodermis. The Plant Journal 27, 191-201.
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Hegmans, A., Sabat, M., Baxter, I., Freisinger, E., and Lippert, B. (1998). Synthetic Ways to Tris(nucleobase) Complexes Derived from cis-Diammineplatinum(II) and a Platinum(II) Complex Containing Four Different Ligands, Three of Which Are Nucleobases. Inorg Chem 37, 4921-4928.
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