Thomas Smith

Dr. Tom Smith received his B.S. (1982), M.S. (1984), and Ph.D. (1985) in Biochemistry from the University of Rochester, Rochester, NY. He was a Postdoctoral Research Associate in crystallography (1985-1987), an Assistant Research Scientist (1988-1989), an Assistant Professor (1989-1994), an Associate Professor (1994-1999), and a Professor (1999-2001) at Purdue University, W. Lafayette IN. In 2001, he joined the DDPSC as a Member and Principal Investigator at the same time became an adjunct Professor at Washington University in St. Louis.

RESEARCH | PUBLICATIONS | RESEARCH TEAM | LAB NEWS

Research

My laboratory combines biochemistry and structural biology to elucidate a number of biological problems.

We are currently working on the structures (cryo-EM and crystallographic) of a number of viruses, ABC transporters, carbohydrate recognition complexes, enzymes, and we are using biochemical methods to protect crops with antifungal proteins.

1. Anti-fungal proteins



2. Virus structure/function
• Human Rhinovirus (HRV)
• Cucumber necrosis virus (CNV)
• Cucumber mosaic virus (CMV)
• Murine norovirus (MNV)
• Cowpea Mottle virus (CPMoV)



3. Glutamate Dehydrogenase and Insulin Regulation



4. ABC Transporters
• Nitrate - NrtA
• Bicarbonate - CmpA
• Iron - RutA1
• Zinc - ZnuA